Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00233h Click here for additional data file.

نویسندگان

  • Simon A. James
  • Blaine R. Roberts
  • Dominic J. Hare
  • Martin D. de Jonge
  • Ian E. Birchall
  • Nicole L. Jenkins
  • Robert A. Cherny
  • Ashley I. Bush
  • Gawain McColl
چکیده

Australian Synchrotron, Clayton, Victoria, Commonwealth Scientic and Industrial R Australia The Florey Institute of Neuroscience and Me Kenneth Myer Building, 30 Royal Parade, Pa gawain.mccoll@orey.edu.au; ashley.bush@ Elemental Bio-imaging Facility, University South Wales, Australia Exposure Biology Laboratory, Lautenberg E Department of Preventive Medicine, Icahn York, New York, USA † Electronic supplementary informa 10.1039/c5sc00233h Cite this: Chem. Sci., 2015, 6, 2952

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Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans.

Iron is essential for eukaryotic biochemistry. Systematic trafficking and storage is required to maintain supply of iron while preventing it from catalysing unwanted reactions, particularly the generation of oxidising reactive species. Iron dyshomeostasis has been implicated in major age-associated diseases including cancers, neurodegeneration and heart disease. Here, we employ population-level...

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Persistent four-coordinate iron-centered radical stabilized by π-donation† †Electronic supplementary information (ESI) available: Experimental, crystallographic, computational details, and crystal data for 2, 4, 5 and 8. CCDC 1057111–1057113 and 1425703. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc02601f Click here for additional data file. Click here for additional data file.

Institute for Materials Chemistry and Kasugakoen, Kasuga, Fukuoka 816-8580, Ja Department of Chemistry, Graduate Schoo Sendai 980-8578, Japan Institute for Materials Chemistry and En Fukuoka 819-0395, Japan CREST, Japan Science and Technology Fukuoka 816-8580, Japan † Electronic supplementary informati crystallographic, computational details, a 1057111–1057113 and 1425703. For ESI other electro...

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2015